Paediatric Chemotherapy regimens
The information contained in these regimens is a statement of consensus of NCCP and Consultant Paediatric Medical Oncologists and Paediatric Haematologist professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. The treatment regimen to be used should take into account factors such as histology, molecular pathology, age, performance status, co-morbidities and the patient’s preference. Each treatment regimen has advantages and disadvantages, and there may be more than one good option. In addition, treatment choices can change over time as more evidence becomes available. Use of these documents is the responsibility of the prescribing clinician and is subject to the HSE.ie terms of use.
Please email any comments or feedback on these regimens to oncologydrugs@cancercontrol.ie.
For information on open clinical trials please refer to the Cancer Trials Ireland website here and also to basket trials here.
Paediatric Chemotherapy regimens
| Regimen |
Indication |
|
Blinatumomab Paediatric Therapy
Regimen
|
P0567a
As monotherapy for the treatment of paediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-cell precursor ALL which is refractory or in relapse after receiving at least two prior therapies or in relapse after receiving prior allogenic hematopoietic stem cell transplantation
|
|
Blinatumomab for Relapsed Paediatric ALL: Consolidation Therapy
Regimen
|
P00707a
As monotherapy for the treatment of paediatric patients aged 1 year or older with high-risk first relapsed Philadelphia chromosome negative CD19 positive B-precursor acute lymphoblastic leukaemia (ALL) as part of the consolidation therapy.
|
|
Pembrolizumab Paediatric Monotherapy
Regimen
|
P00711a
As monotherapy for the treatment of paediatric patients aged 3 years and older with relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) who have failed autologous stem cell transplant (ASCT) or following at least two prior therapies when ASCT is not a treatment option
P00711b
As monotherapy for the adjuvant treatment of adolescents aged 12 years and older with Stage IIB or IIC melanoma and who have undergone complete resection.
|
|
Dinutuximab beta and Isotretinoin Therapy
Regimen
|
P0548a
For the treatment of high-risk neuroblastoma in patients aged 12 months and above, who have previously received induction chemotherapy and achieved at least a partial response, followed by myeloablative therapy and stem cell transplantation, as well as patients with history of relapsed or refractory neuroblastoma, with or without residual disease. Prior to the treatment of relapsed neuroblastoma, any actively progressing disease should be stabilised by other suitable measures.
|
|
Larotrectinib Monotherapy-Paediatric
Regimen
|
P00760a
For the treatment of paediatric patients with solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion,
- who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and
- who have no satisfactory treatment options
|
